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Angioid Streaks

Description

Angioid streaks are irregular tracts emanating from a ring of peripapillary atrophy, believed to be irregular ruptures of Bruch’s membrane. They are associated with atrophic degeneration of the retinal pigment epithelium and rupture or absence of the choriocapillaris. The most frequent complication that threatens visual acuity is the development of choroidal neovascularization in the macular region, although most patients remain asymptomatic. Angioid streaks can be associated with systemic diseases in more than 50% of cases, such as pseudoxanthoma elasticum, Paget’s disease, beta-thalassemia, sickle cell anemia, Ehlers-Danlos syndrome, among others. It is an uncommon pathology, and timely diagnosis is important, primarily in patients with family history, as well as the prevention of trauma given the potential ophthalmological complications that may arise, such as subretinal hemorrhages due to the fragility of Bruch’s membrane, as changes occur in its ultrastructure; specifically in the intermediate elastic layer and the collagenous layer.

Comments

Tests performed (equipment):

CLARUS 700:
  1. Retinography of the right eye showing mild angioid streaks.
  2. Retinography of the left eye showing angioid streaks and a pigmented temporal neovascular membrane.
  3. Autofluorescence of the right eye revealing angioid streaks emanating from the optic disc as hypoautofluorescent areas with hyperautofluorescent borders.
  4. Autofluorescence of the left eye showing angioid streaks and the neovascular membrane.

Indication

Clinical Case

A 56-year-old male referred from the emergency department for a neovascular membrane in the left eye. No relevant ophthalmological or medical history of note. His visual acuity is 20/20 in both eyes. Biomicroscopy shows no alterations in the anterior segment, but funduscopic examination reveals the presence of angioid streaks in both eyes with a pigmented neovascular membrane in the left eye and subretinal fluid (figures 1 and 2). It is decided to initiate treatment with monthly intravitreal triple anti-angiogenic therapy with follow-up at four months, at which point inactivity of the neovascular membrane is observed, and a treat and extend treatment strategy is initiated, maintaining the membrane inactive over time. The hypoautofluorescence in the angioid streaks is evident in the autofluorescence, making the lesions more apparent (figures 3 and 4).