The dislocation or subluxation of the crystalline lens can be caused by multiple factors, including trauma, pseudoexfoliation, genetic diseases such as Marfan or Weill-Marchesani syndromes, familial ectopia lentis, or iatrogenic factors.
In these cases, treatment consists of lens extraction through pars plana vitrectomy and the placement of an intraocular lens. Given the absence of capsular support, options include implantation of an angle-supported intraocular lens, iris-fixated lens, or scleral-fixated lens. Although all options are valid, currently the preference is to implant the intraocular lens in the most physiological position possible to avoid complications such as corneal decompensation, secondary glaucoma, or uveitis. In selected cases, the patient may be left aphakic.