Green autofluorescence: a main lesion is observed in the macula, with a gradual descent of the macula in a stream, and with hyperautofluorescence of the orange pigment deposits. A hypoautofluorescent mottling is observed in the macula, indicating diffuse atrophy of the RPE. Another much smaller focus is observed superonasally to the macula.
Chronic central serous chorioretinopathy (CSCR) is a condition characterized by persistent accumulation of subretinal fluid in the macular region resulting from dysfunction of the retinal pigment epithelium (RPE) and the outer blood-retinal barrier. On optical coherence tomography (OCT), CSCR is manifested by serous detachment of the less dome-shaped neuroepithelium and occasionally RPE detachments (RPE). Fluorescein angiography (FA) typically shows leaky spots, along with more diffuse hyperfluorescent plaques. On indocyanine green angiography (ICG), placoid hyperfluorescence is seen, indicating patches of choroidal hyperpermeability.