Solitary congenital hypertrophy of the retinal pigment epithelium (CHPRE)

Color retinography: solitary HCEPR: pigmented lesion with lacunae inside followed for 25 years

WF color retinography: solitary HCEPR and temporal chorioretinal folds

Multimodal image: Solitary HCEPR - OCT (A): EPR with increased signal at the edges, with thinning of the neurosensory retina and lacunae with increased signal passage inside. - Green filter (B): visualization of the lesion by location in the EPR - Green autofluorescence (C): intense and well-defined hypoautofluorescence - Infrared (D): Pigmented area is highlighted

Dr. Pablo Gili Manzanaro

Description

Solitary HCEPR is a single, highly pigmented, flat lesion with well-defined borders, usually located in the mid-periphery. It may be surrounded by a halo of pigmentation and contain clear lacunae in 43% of cases. It is usually asymptomatic, may experience slow growth, and is not associated with systemic pathology.

Comments

This lesion must be differentiated from other pigmented fundus lesions. Multimodal imaging techniques help to localize the lesion.

Indication

Asymptomatic 65-year-old woman with a solitary, strongly pigmented fundus lesion in left eye. This lesion has been followed for 25 years, experiencing slow growth with an increase in the lacunae within it.