Espacio especializado de Retinografías del Ultra Gran Campo adquiridas con CLARUS y que forman parte del ecosistema RetinaClub.
retina.club
Space dedicated to dissemination in the specialty of ophthalmologic retina that has the first Retina Atlas in Spanish.
![Clarus Club. Javier Montero, MD.
Summary of Key Features of RPE Apertures and Lipid Globules/Caverns
🔹 RPE Apertures
• Well-defined discontinuities in the retinal pigment epithelium (RPE).
• Typically associated with longstanding drusenoid PEDs.
• Characterized by increased transmission on OCT, indicating RPE loss.
• Frequently linked to progression towards atrophy and outer retinal degeneration.
🔹 Lipid Globules / Caverns
• Round, hyporeflective structures observed in the choroid or sub-RPE space.
• Historically known as Friedman Lipid Globules.
• Possibly represent lipid accumulation or degenerative changes.
• Their presence is associated with metabolic dysfunction, impaired clearance of extracellular material, and potential disease progression in AMD.
Bibliography / References
1. Systematic review of prognostic factors associated with progression to late age-related macular degeneration: PINNACLE study report 2
• Hagag AM, Kaye R, Hoang V, et al. Survey of Ophthalmology. 2024;69:165–172. [DOI: 10.1016/j.survophthal.2023.10.010] 
2. Ten-Year Progression From Intermediate to Exudative Age-Related Macular Degeneration and Risk Factors: Bundang AMD Cohort Study Report 1
• Joo K, Mun YS, Park SJ, Park KH, Woo SJ. American Journal of Ophthalmology. 2021;224:228–237. [DOI: 10.1016/j.ajo.2020.11.012] 
3. Longitudinal Assessment of Age-Related Macular Degeneration Using Ultrawidefield Imaging
• Authors: [Names]. Journal Name. Year;Volume(Issue):Pages. [DOI] 
4. Five-year incidence, progression and risk factors for age-related macular degeneration: The Age, Gene-Environment Susceptibility Study
• Authors: [Names]. Journal Name. Year;Volume(Issue):Pages. [DOI] 
5. Developing and validating a multivariable prediction model which predicts progression of intermediate to late age-related macular degeneration—The PINNACLE trial protocol
• Authors: [Names]. Journal Name. Year;Volume(Issue):Pages. [DOI] 
#retina #zeiss #clarus #oftalmologia #medicalretina #widefieldretinalimaging #retinaclub #oftalmología](https://retinaclub.es/wp-content/uploads/sb-instagram-feed-images/482334681_984373560324155_5562198797440795210_nfull.webp)
